Publications || HTI Microbe Lab

Highlighted Publications

Nature Commnunications

Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong

Emerg Microbes Infections

Probable airborne transmission of Burkholderia pseudomallei causing an urban outbreak of melioidosis during typhoon season in Hong Kong, China

The Lancet

Respiratory Medicine

The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Clinical Chemistry

Long-Read Sequencing with Hierarchical Clustering for Antiretroviral Resistance Profiling of Mixed Human Immunodeficiency Virus Quasispecies

Clinical Infectious Diseases

Probable Animal-to-Human Transmission of SARS-CoV-2 Delta Variant AY.127 Causing a Pet Shop-Related COVID-19 Outbreak in Hong Kong

The Lancet

Regional Health - Western Pacific

Complementation of contact tracing by mass testing for successful containment of beta COVID-19 variant (SARS-CoV-2 VOC B.1.351) epidemic in Hong Kong

Referred Journal Publications

Wu WG, Shum MH, Wong IT, Lu KK, Lee LK, Leung JS, Lao HY, Lee AW, Hau PT, Chan CT, Wong HF, Fung SK, Wong SC, Ng IC, Ng TT, Chow N, Ho AY, Hung MF, Chow FW, Wong MM, To WK, Lam TT, Luk KS, Siu GK. Probable airborne transmission of Burkholderia pseudomallei causing an urban outbreak of melioidosis during typhoon season in Hong Kong, China. Emerg Microbes Infect. 2023;12(1):2204155.
Su J, Lui WW, Lee Y, Zheng Z, Siu GK, Ng TT, Zhang T, Lam TT, Lao HY, Yam WC, Tam KK, Leung KS, Lam TW, Leung AW, Luo R. Evaluation of Mycobacterium tuberculosis enrichment in metagenomic samples using ONT adaptive sequencing and amplicon sequencing for identification and variant calling. Sci Rep.;13(1):5237.
Lee AW, Chan CT, Wong LL, Yip CY, Lui WT, Cheng KC, Leung JS, Lee LK, Wong IT, Ng TT, Lao HY, Siu GK. Identification of microbial community in the urban environment: The concordance between conventional culture and nanopore 16S rRNA sequencing. Front Microbiol. 2023;14:1164632.
Xie R, Edwards KM, Adam DC, Leung KSM, Tsang TK, Gurung S, Xiong W, Wei X, Ng DYM, Liu GYZ, Krishnan P, Chang LDJ, Cheng SMS, Gu H, Siu GKH, Wu JT, Leung GM, Peiris M, Cowling BJ, Poon LLM, Dhanasekaran V. Resurgence of Omicron BA.2 in SARS-CoV-2 infection-naive Hong Kong. Nat Commun. 2023;14(1):2422.
Tong CZ, Shi WZ, Siu GKH, Zhang AS, Shi ZC. Understanding spatiotemporal symptom onset risk of Omicron BA.1, BA.2 and hamster-related Delta AY.127. Front Public Health. 2022;10:978052.
Leung KSS, Tam KKG, Ng TL, Lao HY, Shek RCM, Ma OCK, Yu SH, Chen JX, Han Q, Siu GKH, Yam WC. Clinical utility of target amplicon sequencing test for rapid diagnosis of drug resistant Mycobacterium tuberculosis from respiratory specimens. Front Microbiol. 2022 (In press).
Wang S, Qin A, Chau LY, Fok EWT, Choy MY, Brackman CJ, Siu GKH, Huang CL, Yip SP, Lee TMH. Amine-Functionalized Quantum Dots as a Universal Fluorescent Nanoprobe for a One-Step Loop-Mediated Isothermal Amplification Assay with Single-Copy Sensitivity. ACS Appl Mater Interfaces. 2022;14(31):35299-35308.
Rajwani R, Galata C, Lee AWT, So PK, Leung KSS, Tam KKG, Shehzad S, Ng TTL, Zhu L, Lao HY, Chan CT, Leung JS, Lee LK, Wong KC, Yam WC, Siu GK (Corresponding author). A multi-omics investigation into the mechanisms of hyper-virulence in Mycobacterium tuberculosis. Virulence. 2022;13(1):1088-1100
Cheng VC, Wong SC, Au AK, Zhang C, Chen JH, So SY, Li X, Wang Q, Lu KK, Lung DC, Chuang VW, Schuldenfrei E, Siu GK, To KK, Li Y, Yuen KY. Explosive outbreak of SARS-CoV-2 Omicron variant is associated with vertical transmission in high-rise residential buildings in Hong Kong. Build Environ. 2022 1;221:109323.
Kok KH, Wong SC, Chan WM, Wen L, Chu AW, Ip JD, Lee LK, Wong IT, Lo HW, Cheng VC, Ho AY, Lam BH, Tse H, Lung D, Ng KNH, Au AK, Siu GK, Yuen KY. Co-circulation of two SARS-CoV-2 variant strains within imported pet hamsters in Hong Kong. Emerg Microbes Infect. 2022;11(1):689-698
Chan W, Chow FW, Tsang CC, Liu X, Yao W, Chan TT, Siu GK, Ho AY, Luk KS, Lau SK, Woo PC. Induction of amphotericin B resistance in susceptible Candida auris by extracellular vesicles. Emerg Microbes Infect. 2022;1-40.
Zhu L, Lee AW, Wu KK, Gao P, Tam KK, Rajwani R, Chaburte GC, Ng TT, Chan CT, Lao HY, Yam WC, Kao RY, Siu GKH. Screening Repurposed Antiviral Small Molecules as Antimycobacterial Compounds by a Lux-Based phoP Promoter-Reporter Platform. Antibiotics (Basel). 2022;11(3):369.
Wong RC, Wong AH, Ho YI, Siu GK, Lee LK, Leung EC, Lai RW. Application of digital PCR to determine the reliability of Xpert Xpress SARS-CoV-2 assay with envelope (E) gene negative and nucleocapsid (N2) gene positive results. Diagn Microbiol Infect Dis. 2022;103(4):115726.
Chan JF, Siu GK, Yuan S, Ip JD, Cai JP, Chu AW, Chan WM, Abdullah SMU, Luo C, Chan BP, Yuen TT, Chen LL, Chik KK, Liang R, Cao H, Man Poon VK, Chan CC, Leung KH, Tam AR, Tsang OT, Chan JM, To WK, Lam BH, Lee LK, Lo HW, Wong IT, Leung JS, Wong EY, Chu H, Yip CC, Cheng VC, Chan KH, Tse H, Lung DC, Ng KH, Au AK, Hung IF, Yuen KY, To KK. Probable Animal-to-Human Transmission of SARS-CoV-2 Delta Variant AY.127 Causing a Pet Shop-Related COVID-19 Outbreak in Hong Kong. Clin Infect Dis. 2022 ;ciac171
Chan CTM, Leung JSL, Lee LK, Lo HWH, Wong WYK, Wong DSH, Ng TTL, Lao HY, Lu KK, Jim SHC, Yau MCY, Lam JYW, Ho AYM, Luk KS, Yip KT, Que TL, To KKW, Siu GKH. A low-cost TaqMan minor groove binder probe-based one-step RT-qPCR assay for rapid identification of N501Y variants of SARS-CoV-2. J Virol Methods. 2022 ;299:114333
Lao HY, Ng TTL, Wong RYL, Wong CST, Lee LK, Wong DSH, Chan CTM, Jim SHC, Leung JSL, Lo HWH, Wong ITF, Yau MCY, Lam JYW, Wu AKL, Siu GKH. The Clinical Utility of Two High-Throughput 16S rRNA Gene Sequencing Workflows for Taxonomic Assignment of Unidentifiable Bacterial Pathogens in Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry. J Clin Microbiol. 2022;60(1):e0176921.
Wong RCW, Lee MK, Siu GK, Lee LK, Leung JSL, Leung ECM, Ho YLL, Lai RWM. Healthcare workers acquired COVID-19 disease from patients? An investigation by phylogenomics. J Hosp Infect. 2021;S0195-6701(21)
Mok BW, Liu H, Deng S, Liu J, Zhang AJ, Lau SY, Liu S, Tam RC, Cremin CJ, Ng TT, Leung JS, Lee LK, Wang P, To KK, Chan JF, Chan KH, Yuen KY, Siu GK, Chen H. Low dose inocula of SARS-CoV-2 Alpha variant transmits more efficiently than earlier variants in hamsters. Commun Biol. 2021;4(1):1102.
Cheng VCC, Fung KSC, Siu GKH, Wong SC, Cheng LSK, Wong MS, Lee LK, Chan WM, Chau KY, Leung JSL, Chu AWH, Chan WS, Lu KK, Tam KKG, Ip JD, Leung KSS, Lung DC, Tse H, To KKW, Yuen KY. Nosocomial outbreak of COVID-19 by possible airborne transmission leading to a superspreading event. Clin Infect Dis. 2021;73(6):e1356-e1364.
Lu L, Chu AWH, Zhang RR, Chan WM, Ip JD, Tsoi HW, Chen LI, Cai JP, Lung DC, Tam AR, Yau YS, Kwan MYW, To WK, Tsang OTY, Lee LLY, Yi H, Ip TC, Poon RWS, Siu GKH, Mok BWY, Cheng VCC, Chan KH, Yuen KY, Hung IFN, To KKW. The impact of spike N501Y mutation on neutralizing activity and RBD binding of SARS-CoV-2 convalescent serum. EBioMedicine. 2021 ;71:103544.
Meng F, Siu GK, Mok BW, Sun J, Fung KSC, Lam JY, Wong NK, Gedefaw L, Luo S, Lee TMH, Yip SP, Huang CL. Viral MicroRNAs Encoded by Nucleocapsid Gene of SARS-CoV-2 Are Detected during Infection, and Targeting Metabolic Pathways in Host Cells. Cells. 2021;10(7):1762
Cheng VCC, Siu GKH, Wong SC, Au AKW, Ng CSF, Chen H, Xin L, Lee LK, Leung JSL, Lu KK, Lo HWH, Wong EYK, Luk S, Lam BHS, To WK, Lee RA, Lung DC, Kwan MYW, Tse H, Chuang SK, To KKW, Yuen KY. Complementation of contact tracing by mass testing for successful containment of beta COVID-19 variant (SARS-CoV-2 VOC B.1.351) epidemic in Hong Kong. Lancet Reg Health West Pac. 2021;17:100281.
Teng JLL, Luo R, Tang BSF, Fong JYH, Wang L, Jia L, Wong CKS, Chan E, Leung AWS, Siu GKH, Chiu TH, Fung AMY, Wu AKL, Yeung ML, Lau SKP, Woo PCY. High Prevalence and Mechanism Associated With Extended Spectrum Beta-Lactamase-Positive Phenotype in Laribacter hongkongensis. Front Microbiol. 2021; 9;12:618894
Leung KSS, Ng TTL, Wu AKL, Yau MCY, Lao HY, Choi MP, Tam KKG, Lee LK, Wong BKC, Ho AYM, Yip KT, Lung KC, Liu RWT, Tso EYK, Leung WS, Chan MC, Ng YY, Sin KM, Fung KSC, Chau SKY, To WK, Que TL, Shum DHK, Yip SP, Yam WC, Siu GK (Corresponding author). A Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China. Emerg Infect Dis. 2021;27(1):196-204.
Siu GK, Lee LK, Leung KS, Leung JS, Ng TT, Chan CT, Tam KK, Lao HY, Wu AK, Yau MC, Lai YW, Fung KS, Chau SK, Wong BK, To WK, Luk K, Ho AY, Que TL, Yip KT, Yam WC, Shum DH, Yip SP. Will a new clade of SARS-CoV-2 imported into the community spark a fourth wave of the COVID-19 outbreak in Hong Kong? Emerg Microbes Infect. 2020;9(1):2497-2500.
Tafess K, Beyen TK, Girma S, Girma A, Siu G. Spatial clustering and genetic diversity of Mycobacterium tuberculosis isolate among pulmonary tuberculosis suspected patients, Arsi Zone, Ethiopia. BMC Pulm Med. 2021;21(1):206.
Tafess K, Ng TT, Lao HY, Leung KS, Tam KK, Rajwani R, Tam ST, Ho LP, Chu CM, Gonzalez D, Sayada C, Ma OC, Belete HN, Ameni G, Yam WC, Siu GK. Targeted Sequencing Workflows for Comprehensive Drug Resistance Profiling of Mycobacterium tuberculosis cultures using Illumina MiSeq and Nanopore MinION: Comparison of analytical and diagnostic performance, turnaround time and cost. Clin Chem. 2020;66(6):809-820.
Shenkutie AM, Yao MZ, Siu GK, Wong BKC, Leung PH. Biofilm-Induced Antibiotic Resistance in Clinical Acinetobacter baumannii Isolates. Antibiotics (Basel). 2020;9(11):817.
Yip CC, Chan WM, Ip JD, Seng CW, Leung KH, Poon RW, Ng AC, Wu WL, Zhao H, Chan KH, Siu GK, Ng TT, Cheng VC, Kok KH, Yuen KY, To KK. Nanopore Sequencing Reveals Novel Targets for Detection and Surveillance of Human and Avian Influenza A Viruses. J Clin Microbiol. 2020;58(5).
Suen LKP, Lung VYT, Boost MV, Au-Yeung CH, Siu GKH. Microbiological evaluation of different hand drying methods for removing bacteria from washed hands. Sci Rep. 2019. 24;9(1):13754.
Tam KK, Leung KS, Siu GK, Chang KC, Wong SS, Ho PL, Leung EK, Yam WC. Direct detection of pyrazinamide resistance of Mycobacterium tuberculosis using pncA PCR Sequencing. J Clin Microbiol. 2019. 26;57(8).
Haile B, Tafess K, Zewude A, Yenew B, Siu GK, Ameni G. Spoligotyping and drug sensitivity of Mycobacterium tuberculosis isolated from pulmonary tuberculosis patients in the Arsi Zone of southeastern Ethiopia. New Microbes New Infect. 2019;33:100620.
Leung KS, To SW, Chen JH, Siu GK, Chan KC, Yam WC. Molecular characterization of HIV-1 minority subtypes in Hong Kong: A recent epidemic of CRF07_BC among the men who have sex with men population. Curr HIV Res. 2019;17(1):53-64.
Suen LKP, Siu GKH, Guo YP, Yeung SKW, Lo KYK, O'Donoghue M. The public washroom - friend or foe? An observational study of washroom cleanliness combined with microbiological investigation of hand hygiene facilities. Antimicrob Resist Infect Control. 2019 ;8:47
Leung KS, Siu GK, Tam KK, Ho PL, Wong SS, Leung EK, Yu SH, Ma OC, Yam WC. Diagnostic Evaluation of An In-House Developed Single-tube, Duplex, Nested IS6110 Real-Time PCR assay for Rapid Pulmonary Tuberculosis Diagnosis. Tuberculosis (Edinb).2018; 112:120-125
Rajwani R, Shehzad S, Siu GKH. MIRU-profiler: a rapid tool for determination of 24-loci MIRU-VNTR profiles from assembled genomes of Mycobacterium tuberculosis. PeerJ.2018; 6:e5090.
Lee AWT, Lam JKS, Lam RKW, Ng WH, Lee ENL, Lee VTY, Sze PP, Rajwani R, Fung KSC, To WK, Lee RA, Tsang DNC, Siu GKH. Comprehensive evaluation of the MBT STAR-BL module for simultaneous bacterial identification and β-lactamase-mediated resistance detection in Gram-negative rods from cultured isolates and positive blood cultures. Front Microbiol. 2018;9:334.
Tafess K, Beyen TK, Abera A, Tasew G, Mekit S, Sisay S, Tadesse L, Siu GKH. Treatment Outcomes of Tuberculosis at Asella Teaching Hospital, Ethiopia: Ten Years' Retrospective Aggregated Data. Front Med (Lausanne). 2018; 5:38
Rajwani R, Yam WC, Zhang Y, Kang Y, Wong BKC, Leung KSS, Tam KKG, Tulu KT, Zhu L, Siu GKH. Comparative Whole-Genomic Analysis of an Ancient L2 Lineage Mycobacterium tuberculosis Reveals a Novel Phylogenetic Clade and Common Genetic Determinants of Hypervirulent Strains. Front Cell Infect Microbiol. 2018 ;7:539.
Leung KS, Siu GK, Tam KK, To SW, Rajwani R, Ho PL, Wong SS, Zhao WW, Ma OC, Yam WC. Comparative Genomic Analysis of Two Clonally Related Multidrug Resistant Mycobacterium tuberculosis by Single Molecule Real Time Sequencing. Front Cell Infect Microbiol. 2017;7:478
Tam KK, Leung KS, To SW, Siu GK, Lau TC, Shek VC, Tse CW, Wong SS, Ho PL, Yam WC. Direct detection of Mycobacterium tuberculosis and drug resistance in respiratory specimen using Abbott Realtime MTB detection and RIF/INH resistance assay. Diagn Microbiol Infect Dis. 2017;89(2):118-124
Dheda K, Gumbo T, Maartens G, Dooley KE, McNerney R, Murray M, Furin J, Nardell EA, London L, Lessem E, Theron G, van Helden P, Niemann S, Merker M, Dowdy D, Van Rie A, Siu GK, Pasipanodya JG, Rodrigues C, Clark TG, Sirgel FA, Esmail A, Lin HH, Atre SR, Schaaf HS, Chang KC, Lange C, Nahid P, Udwadia ZF, Horsburgh CR Jr, Churchyard GJ, Menzies D, Hesseling AC, Nuermberger E, McIlleron H, Fennelly KP, Goemaere E, Jaramillo E, Low M, Jara CM, Padayatchi N, Warren RM. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis. Lancet Respir Med. 2017; pii: S2213-2600(17)30079-6 – Review Article
Yuan L, Yu Y, Zhu Y, Li Y, Li C, Li R, Ma Q, Siu GK, Yu J, Jiang T, Xiao J, Kang Y. GAAP: Genome-organization-framework-Assisted Assembly Pipeline for prokaryotic genomes. BMC Genomics. 2017 ; 18(Suppl 1):952
To SWC, Siu GKH, Wong KH, Chan KC, Yuen KT, Ng HM & Yam WC. Utilization of a duplex hybprobe real-time PCR to detect and estimate IL-28B polymorphisms prevalence among HIV/HCV co-infected patients in Hong Kong. J Med Microb Diagn. 2015; 4:194
Siu GK, Chen JH, Ng TK, Lee RA, Fung KS, To SW, Wong KC, Cheung S, Wong IW, Tam MM, Lee SS, Yam WC. Performance Evaluation of the Verigene Gram-Positive and Gram-Negative Blood Culture Test for Direct Identification of Bacteria and Their Resistance Determinants from Positive Blood Cultures in Hong Kong. PLoS One. 2015;10(10):e0139728
Chen JH, She KK, Kwong TC, Wong OY, Siu GK, Leung CC, Chang KC, Tam CM, Ho PL, Cheng VC, Yuen KY, Yam WC. Performance of the new automated Abbott RealTime MTB assay for rapid detection of Mycobacterium tuberculosis complex in respiratory specimens. Eur J Clin Microbiol Infect Dis. 2015;34(9): 1827-32. Applicant’s contribution: • Analyzed the data, and wrote paper
Luo Y, Siu GK (Co-first author), Yeung AS, Chen JH, Ho PL, Leung KW, Tsang JL, Cheng VC, Guo L, Yang J, Ye L, Yam WC. Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China. J Med Microbiol. 2015; 64(pt 1):18-24
LanY, Lam JT, Siu GK, Yam WC, Manson AJ, Lam JK. Cationic amphipathic D-enantiomeric antimicrobial peptides with in vitro and ex vivo activity against drug-resistant Mycobacterium tuberculosis. Tuberculosis (Edinb). 2014; 94(6):678-89
Siu GK, Yam WC, Zhang Y, Kao RY. An upstream truncation of furA-katG operon confer high-level isoniazid resistance in a Mycobacterium tuberculosis clinical isolate with no known resistance associated mutations. Antimicrob Agents Chemother. 2014; 58(10):6093-100
Yam WC, Siu GK, Ho PL, Ng TK, Que TL, Yip EK, Fok CP, Chen JH, Cheng VC, Yuen KY. Evaluation of LightCycler® Methicillin-Resistant Staphylococcus aureus (MRSA) Advanced Test for the detection of nasal colonizing MRSA. J Clin Microbiol. 2013; 51(9):2869-74
Chen JH, Ho PL, Kwan GS, She KK, Siu GK, Cheng VC, Yuen KY, Yam WC Direct Bacterial Identification in Blood Cultures using two commercial MALDI-TOF mass spectrometry systems. J Clin Microbiol. 2013; 51(6):1733-9. 51(6):1733-9
Yam WC, Siu KH. Rapid Identification of Mycobacteria and Rapid Detection of Drug Resistance in Mycobacterium tuberculosis in Cultured Isolates and in Respiratory Specimens. Methods Mol Biol. 2013; 943:171-99
Vermeer LS, Lan Y, Abbate V, Ruh E, Bui TT, Wilkinson LJ, Kanno T, Jumagulova E, Kozlowska J, Patel J, Mclntyre CA, Yam WC, Siu GK, Atkinson RA, Lam KW, Bansal SS, Drake AF, Mitchell GH, Mason AJ.Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides. J Biol Chem. 2012; 287(41):34120-33
Zhu C, Zhang Y, Shen Y, Siu GK, Wu W, Qian X, Deng G, Xu Y, Lau R, Fan X, Zhang W, Lu H, Yam WC. Molecular characterization of fluoroquinolone-resistant Mycobacterium tuberculosis clinical isolates from Shanghai, China. Diagn Microbiol Infect Dis. 2012;73(3):260-3
Lee AS, Ong DC, Wong JC, Siu GK, Yam WC. High-resolution melting analysis for the rapid detection of fluoroquinolone and streptomycin resistance in Mycobacterium tuberculosis. PLoS One. 2012;7(2):e31934.
Siu GK, Zhang Y, Lau CK, Lau RW, Ho PL, Yew WW, Tsui KW, Cheng VC, Yuen KY Yam WC. Mutations outside rifampicin resistance determining region associated with rifampicin resistance in Mycobacterium tuberculosis. J Antimicrob Chemother, 2011. 66, 730-3.
Cheng VC, Yam WC, Tsang LL, Yau MC, Siu GK, Wong SC, Chan JF, To KK, Tse H, Hung IF, Tai JW, Ho PL, Yuen KY. Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan and bile salts. J Clin Microbiol. 2012; 50(5):1571-9
Cheng VC, Yam WC, Lam CT, Siu GK, Chan FW, To KW, Li WS, Tai WM, Ho PL, Yuen KY .Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong. Eur J Clin Microbiol Infect Dis. 2011;30(11):1371-81
Siu GK, Tam YH, Ho PL, Lee AS, Que TL, Tse WS, Yip KT, Lam TH, Cheng VC, Yuen KY, Yam WC. Direct detection of isoniazid-resistant Mycobacterium tuberculosis in respiratory specimens by multiplex allele-specific PCR. Diagn Microbiol Infect Dis. 2010. 69, 51-58
Ong DC, Yam WC, Siu GK, Lee AS. Rapid detection of rifampicin- and isoniazid-resistant Mycobacterium tuberculosis by high-resolution melting analysis. J Clin Microbiol. 2010 Apr;48(4):1047-54
Lau RW, Ho PL, Kao RY, Siu GK, Cheng VC, Yuen KY, Yam WC. Rapid diagnosis of multidrug-resistant smear-positive pulmonary tuberculosis. Int J Antimicrob Agents. 2010 Feb;35(2):202-3
Boost MV, O'Donoghue MM, Siu KH. Characterisation of methicillin-resistant Staphylococcus aureus isolates from dogs and their owners. Clin Microbiol Infect. 2007;13(7):731-3

Book Chapter

Refereed Conference Papers

NG TTL, Siu GK. The journey to rapid antibiotic resistance detection in Mycobacterium tuberculosis with direct sequencing of sputum samples: the benefits, the precautions, and the solution. Australian Society for Microbiology Annual Scientific Meeting 2022. Zoom. 11th - 14 July 2022
Siu GK. Whole-genome sequencing of COVID-19 cases in Hong Kong: development of a geophylogenetic database and characterisation of SARS-CoV-2 variants circulating in the community. Health Research Symposium. Hong Kong, China. 23 November 2022
Galata C, Siu GK. Determination of the functional impact of overexpressed phoP gene on mycobacterial virulence using the zebrafish model. 14th International Conference on Research in Life-Sciences & Health care (ICRLSH). London, UK. 10-11 September 2021
Zhu L, Siu GK. Construction promoter-lux reporter platforms in Mycobacterium bovis BCG for screening new TB drugs. Keystone Symposia Conference. Keystone, Colorado, US, 16-20 January 2020
Siu GK. Determination of Genotypic Drug Susceptibility Patterns of Mycobacterium tuberculosis Directly from Respiratory Specimens Using Nanopore Sequencing. Nanopore Tech tour. Shanghai, China, 19-21 September 2019
Siu GK. Multiplex identification of bacteria and drug resistant determinants from positive blood cultures. 5th congress of AAMLS Busan, Korea, 21-24 Sept 2017
Tafess K, Siu GK. Diagnosis of drug-resistant Mycobacterium tuberculosis by targeted sequencing using MinION Technology. Nanopore Community Meeting. London, UK, 1-2 December 2016
Rajwani R, Siu GK. Comparative genomic analysis of hypervirulent Mycobacterium tuberculosis strains and closely related hypovirulent strains reveals novel mutations associated with enhanced growth during macrophage infection. Tuberculosis 2016 – Interdisciplinary research on tuberculosis and pathogenic mycobacteria. Institut Pasteur, Paris, France, 19-23 September 2016
Siu GK. Rapid detection of resistance against β-lactam antibiotics from cultured isolates and blood culture using MALDI-TOF Mass Spectrometry. 9th Shanghai International Symposium on Infectious Diseases and 10th Annual Meeting of Chinese American Association of Clinical Microbiology Joint Meeting. Shanghai, China, 2-4 July, 2016
Rajwani R, Siu GK. Genetic basis of hypervirulence in Mycobacterium tuberculosis strains isolated from patients suffering from tuberculous meningitis. Keystone Symposia Conference. Keystone, Colorado, US, 28 Feb – 3 March 2016
Siu GK, Chen JH, Yam WC. Rapid Diagnosis of Sepsis by Direct Identification of Bacteria and Resistance Determinants from Positive Blood Cultures Using Verigene BC-GP and BC-GN test: A Multicenter Evaluation in Hong Kong. The 25th European Congress of Clinical Microbriology and Infectious Diseases (ECCMID 2015). Copenhagen, Denmark, 25-28 April, 2015
Siu GK, Kwong TC, Yam WC. Large-scale evaluation of an integrated rapid molecular testing of multidrug resistant Mycobacterium tuberculosis in respiratory specimens. The 24th European Congress of Clinical Microbiology and Infectious Disease (ECCMID 2014). Barcelona Spain, 10-13 May, 2014.