Projects || HTI Microbe Lab

Discovery of small-molecule anti-virulence agents for Mycobacterium tuberculosis infection - From high-throughput screening to infection model validation
Establishment of clinical workflow for rapid identification of pathogens and antimicrobial resistance from infected body fluids – Metagenomic vs targeted amplicon sequencing approach
Whole-Genome Sequencing of COVID-19 Cases in Hong Kong: Development of A Geo-Phylogenetic Database and Characterisation of SARS-CoV-2 Variants Circulating in The Community
Unveiling the pathogenic mechanisms of tuberculous meningitis caused by hypervirulent Mycobacterium tuberculosis strains using multi-omic analysis coupled with a multiple fluorescent zebrafish infection model
Portable nanopore sequencing-based assay for rapid diagnosis of bloodstream infection
Development of Nanopore Sequencing-based Platform for Rapid Monitoring of COVID-19 Transmission in Hong Kong
Combined genomic and transcriptomic approach to elucidate the mechanism underlying enhanced intramacrophage survivability of hypervirulent Mycobacterium tuberculosis
Portable Nanopore sequencing for rapid diagnosis of drug resistant tuberculosis
Real-time, portable Nanopore-type sequencing for rapid HIV genotyping and drug resistance monitoring
Development of low-cost genotyping assay for routine clinical detection of HIV-1 integrase inhibitor resistance
Rapid and comprehensive prediction of first and second-line drug resistance in Mycobacterium tuberculosis directly from respiratory specimens using massive parallel targeted sequencing: A prospective study
Prediction of incident active TB in PLHIV by detection of free-circulating M. tuberculosis DNA in patient plasma: A retrospective longitudinal study
Modeling severe COVID-19 in golden Syrian hamsters
Spatiotemporal prediction and real-time early warning of COVID-19 onset risk
Provision of Services for Routine Surveillance of Antimicrobial Resistant Microorganisms in Food in Hong Kong
Developing a novel liquid biopsy-based molecular assay for the diagnosis tuberculosis
Establishment of metagenomic map of urban microbiomes and antimicrobial resistance in HK
Matrix-Assisted Laser Desorption /Ionization Time-Of-Flight (MALDI-TOF) MS System for Microbial Identification
Development of next generation molecular diagnostics for tuberculosis (TB): from latent TB in HIV patients to multiple and extensively drug resistant active TB
Advanced microsystem for real-time tracking & imaging of live bacteria